Immune Cell Metabolism and Immuno-Oncology

With the significant successes of immune checkpoint blockade and adoptive cellular therapy, immunotherapy has now become an established treatment option to effectively treat cancer. However, full potential this modality yet be realized, as there are many additional mechanisms whereby tumors continue evade destruction. To end, metabolic reprogramming by cancer cells serves not only promote their own growth but also create immunosuppressive tumor microenvironment. The microenvironment inhibits antitumor effector function supports differentiation suppressive cells. In review, we delineate major programs Furthermore, discuss role so-called checkpoints that evasion growth. Finally, review current future strategies target metabolism in order simply inhibit enhance responses. Such have great breadth depth for targeting checkpoints. Expected final online publication date Annual Review Cancer Biology, Volume 7 is April 2023. Please see http://www.annualreviews.org/page/journal/pubdates revised estimates.